It is normally located in the major salivary glands. They are seen as reddishyellow masses, which may be solid or a mixture of solid and cystic. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Malignant myoepithelioma of the salivary gland is discussed in. Myoepithelioma of the salivary gland was formally categorized as a salivary neoplasm in 1991 2,3. Myoepithelial carcinoma an overview sciencedirect topics. Many tumors are heterogeneous, containing an admixture of epithelioid and spindled cells, reticular areas merging with solid figure 1. Normal salivary gland cytology non diagnosticcontinued e.
Benign myoepithelioma of the lung a case report and. Fewer than 100 cases had been reported through 1993. Myoepithelioma of minor salivary gland of cheek cytology description nuclear grooves, intranuclear cytoplasmic inclusions, nuclear striations zebra lines, myxoid matrix. This included 6 cases of mucoepidermoid carcinoma, 3. They are essentially represented by the mucoepidermoid carcinoma, the adenoid cystic carcinoma and the pleomorphic adenoma. It has a relatively poor clarification of its biologic behavior, clinicopathologic features and immunohistochemical profile. Composed of a mixed population of spindled, epithelioid, and plasmacytoid cells arranged around a. Fine needle aspiration cytology of salivary gland lesions. Only 1% of all salivary gland neoplasms are myoepitheliomas. Abstract myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. In this report, we describe two cases of a benign myoepithelioma of the p arotid gland. Myoepitheliomas are rare benign neoplasias of the salivary gland, more commonly found in the parotid 1,2, being responsible for less than 7% of salivary gland tumors.
Original research myoepithelioma of the p arotid gland. Subsequently, it was designated variously as the parotid clear cell adenoma probably of myoepithelial derivation or adenomyopeithelioma. The treatment of myoepitheliomas is complete removal of the tumor. Review and updates of immunohistochemistry in selected. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Two cases of myoepithelioma occurring in the parotid gland were reported. Myoepitheliomas mes are rare tumors of the parotid gland. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Myoepithelioma of the lung european journal of cardio.
Malignant myoepithelioma of the parotid gland crissman. Pdf myoepithelioma of a minor salivary gland of the. Vimentin and s100 protein are very sensitive but nonspecific immunohistochemical markers of neoplastic myoepithelium. Myoepithelial carcinoma malignant myoepithelioma of the parotid. Myoepithelioma of minor salivary gland on the base of the tongue. To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation. Myoepithelioma is a rare benign myoepithelial tumour and its malignant counterpart is myoepithelial carcinoma. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion. Presentation may be the same as other benign salivary gland tumors. Myoepithelial carcinoma malignant myoepithelioma of the parotid gland arising in a pleomorphic adenoma. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Tani, lambert skoog, in comprehensive cytopathology third edition, 2008.
Myoepithelioma of parotid gland presenting as infraauricular. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells. Summarythe present paper describes the clinical and pathologic features of a benign myoepithelioma of the p arotid gland. Rare primary lesions that have been known to metastasize to the skin include an adenoid cystic carcinoma, an acinic cell carcinoma, a myoepithelial carcinoma, and adenocarcinoma of the salivary gland, 365370 an adenoid cystic carcinoma of the lacrimal gland, 371 an ameloblastoma, 372 a thymoma, 373 an adrenal carcinoma, 374,375 a pheochromocytoma, 376 and carcinomas of the hypopharynx, 377 nasopharynx, 31,378,379 and larynx. Capsules are generally better developed in tumors of the major glands, whereas those arising in the palate or other minor salivary or seromucinous gland sites are circumscribed but not usually encapsulated.
The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. Soft tissue myoepithelial me carcinoma, also known as soft tissue malignant myoepithelioma stmm, and myoepithelioma are rare entities, part of me tumors. Also precursor benign lesions were seen only in 24% of cases n 12. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. Most studies have found that 75% of myoepithelial carcinomas arise in the major salivary glands and that about half arise in precursor lesions. Although they are an important element in many salivary gland tumors, 1 pure myoepitheliomas are rare, accounting for salivary gland tumors. Variability in cellular morphology and stromal composition leads to diagnostic pitfalls on fine. Benign myoepithelioma is extremely rare in the lung, to the best of our knowledge. Histological examination of the second recurrence showed a malignant spindle cell neoplasm with. It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors.
Salivary gland myoepithelioma with focal capsular invasion. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor. Salivary gland basal cell and canalicular adenomas archives. Get a printable copy pdf file of the complete article 2. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral. A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a pleomorphic adenoma of the parotid gland. Myoepitheliomas are rare, benign neoplasms affecting predominantly parotid gland and to a lesser extent minor salivary glands.
Since 1943 when sheldon identified them and characterized them as myoepithelioma, less than 100 cases have been reported in the literature. Despite wide distribution of myoepithelial cells in the bronchial mucous glands, few tumors of myoepithelial origin have been reported in the lung. Conservative treatment that preserves the overlaying palatal mucosa while surgically excising the tumor was carried out under general anesthesia, because the. These tumors can occur in most of the glandular structures like salivary glands, breast and sweat glands of the skin. Original article, clinical report by ear, nose and throat journal.
Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation. The most common site is parotid gland with a few arising in minor salivary glands of the oral cavity and palate. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. We selected 4 cases of small salivary gland myoepitheliomas from the files of the pathology lab of the oral pathology department of the federal university of. Histopathologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and eccentric nuclei arranged in cords and files. Links to pubmed are also available for selected references. Myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 11. Salivary gland malignant myoepithelioma nagao 1998. Hamperl defined tumors containing mainly myoepithelial cells that are composed of three morphologic types. Myoepithelioma, salivary glands, mouse springerlink. Salivary duct stone with cystaspiration yields clear fluid, no more massthen adequate as it explains the scenario bilateral enlarged salivary glands with no definite mass, then adequate however, if mass, and all you get is normal salivary gland tissue.
The tumor cells of the two cases likewise contained myofilaments and gave a positive result for the s. However, they may be malignant and infiltrate locally. These tumors consisted of spindle cells that exhibited an arrangement similar to leiomyoma or fibroma. Abstractmalignant myoepithelioma of salivary gland which is also known as myoepithelial carcinoma is a rare disease. It can be present in individuals of a wide age range including children and adults. Get a printable copy pdf file of the complete article 1. In this report, we describe two cases of a benign myoepithelioma of the parotid gland. Myoepithelioma is more common in adults than in children or adolescents. Only three cases of sinonasal myoepithelioma have been reported in the literature. Voluminous myoepithelioma of the minor salivary glands.
Myoepithelioma of a minor salivary gland of the cheek. Subsequently the tumour recurred twice and was characterised by invasion of the mandible. Salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. The recurrence rate is similar to that of the pleomorphic adenoma 1518%. Pdf myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 11. Pdf myoepithelioma, a benign tumor, occurs with a frequency of 1. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. While myoepithelioma has no specific clinical features, it is accepted pathologically as a distinct entity. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. The benign salivary corpuscular bassinetmyoepithelioma.
Salivary gland malignant myoepithelioma nagao 1998 cancer. Classically, they are found in the parotid gland or palate. They are encapsulated or at least wellcircumscribed tumours and the majority arise in the parotid gland. The histopathology shows several architectural patterns such as trabecular, glandular, partly cystic, and solid. Malignant salivary gland tumors were seen in 16 cases. Myoepithelioma is a rare disease in the salivary gland.
The histological types of primitive salivary gland type tumors arising in the lung are very infrequent. Plasmacytoid myoepithelioma of minor salivary glands. Dedifferentiated salivary gland tumor is a rare, recently recognized tumor type. Case selection was from the files of the armed forces. Dedifferentiated malignant myoepithelioma of the parotid gland. A case of dedifferentiated malignant myoepithelioma in a 59. Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary glands of the oral cavity. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology. Combined myoepithelial carcinoma and myoepithelioma in. Salivary gland myoepithelial carcinoma springerlink. We have located a case report of cutaneous myoepithelial carcinoma occurring on a persons back. Salivary gland cytology and the milan system for reporting.
Myoepithelioma of salivary glands american cancer society journals. Pdf myoepithelioma of minor salivary gland on the base. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. Benign myoepithelialtumor, 2% of salivary gland neoplasms, 6% of minor salivary gland tumors 3rd5thdecade, m.
Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors shaobo zhu, md. Myoepithelioma occurring in minor salivary glands of oral cavity accounts for 26% of all salivary gland myoepitheliomas and palate being the most common site 69. Pdf minimally invasive surgery in a pediatric palatal. Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Jan, 2005 myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Collagenizedstroma, chondroidor chondromyxoidareas looks like pa but without ductal cells. Myoepithelial tumors of the salivary gland including myoepitheliomas benign and myoepithelial carcinomas malignant are a rare group of. We report two patients with myoepithelioma of parotid gland presenting as infraauricular subcutaneous mass. Myoepithelioma is a wellcircumscribed or encapsulated tumor. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. They commonly occur in salivary glands, but they have also been reported in the nasopharynx, larynx, breast and lung 1, 2.
The histological appearance includes solid, myxoid and reticular growth patterns. The diagnosis was made on the basis of characteristic ultrastructural as well as immunohistochemical findings. Sheldon initially published his work on a myoepithelioma in 1943, and first in 1991 and later in 2005 myoepithelioma was recognized from the who as a distinct entity 2, 3. Epithelialmyoepithelial carcinoma of the parotid gland. A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a. Salivary gland like tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes. Myoepithelioma of salivary glands are very rare, accounting for only 1%1. Treatment should be designed as for a benign salivary gland tumor with a margin of normal uninvolved tissue being included within the surgical excision. Mc usually presents as a slowgrowing painless mass arising in the parotid gland, but may involve other salivary glands.
Myoepithelioma is a rare neoplasm of the salivary glands, generally occurring in the parotid gland and less often in the minor accessory salivary gland of the oral cavity. Health, general cancer diagnosis research cancer diagnosis carcinoembryonic antigen genetic aspects cea oncology immunohistochemistry intermediate filament proteins medical research medicine, experimental salivary gland tumors tumor proteins. Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Myoepithelial carcinoma malignant myoepithelioma of the. Pdf salivary gland myoepithelial carcinoma mc or malignant myoepithelioma is a rare entity. Although they are an important element in many salivary gland tumors, 1 pure myoepitheliomas are rare, accounting for of all salivary gland tumors. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Pdf salivary gland myoepithelial carcinoma researchgate. The proportion of parotid myoepitheliomas range from. Aug 26, 2009 myoepithelioma is a rare salivary gland tumor arising from proliferation of myoepithelial cells. Only a few case reports describing ct imaging features of me have been published.
Immunohistochemical evaluation of 25 salivary gland basal cell and canalicular adenomas. It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. Myoepithelioma of minor salivary glands a diagnostic. Previously reported cases have been either benign or, at most, locally aggressive. Benign salivary gland tumors were seen in 38 cases. Tanahashi j, kashima k, daa t, kondo y, kuratomi e, yokoyama s. It can be present in individuals of a wide age range including children and adults the cause of formation of salivary gland myoepithelioma is not wellunderstood, although certain chromosomal alterations and gene mutations have been. Pure accounting for less than 1% of all salivary gland tumors.
They present as bulky, bosselated, slowgrowing tumors that maybecomelarge. Myoepithelioma is a rare and usually benign salivary gland tumor derived from myoepithelial cells. The diagnosis is rendered histopathologically, and it includes the. Analysis of the clinical relevance of histological classification of. Histologically, two distinct neoplastic cell populations were observed in the same tumor mass. Hence, histopathologic examination should be considered to differentiate these tumors. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the. Table 1 2017 who classification of benign epithelial salivary gland tumours.
We describe a myoepithelioma of cervical soft tissue. Myoepithelioma of the parotid gland with extensive. Myoepithelial cells are normal components of salivary glands, sweat glands and breast. Such lesion shows a varied pattern of morphological growth, it may be solid, myxoid or reticular. Pdf spindle cell myoepithelioma of the parotid gland. Losito nsbotti gionna fpasquinelli gminenna pbisceglia m clearcell myoepithelial carcinoma of the salivary glands. Myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Rather, we believe that in general, physicians are simply unaware of its existence. The lesions were clinically suspected to be epidermal cyst. Through 1985, only 42 other cases had been reported in the literature. Malignant myoepithelioma mme of the salivary gland, also known as. Full text full text is available as a scanned copy of the original print version. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands.
Nov 18, 2016 yes, in addition to occurring in the salivary glands, this type of cancer can also occur in the skin or soft tissues. Myoepithelial carcinoma can arise in both minor and major salivary glands but with a predilection for the parotid gland. K5k14positive cells contribute to salivary glandlike. Myoepitheliomas usually occur in the major salivary glands and appear in the subcutis of the ventral neck. The criteria to differentiate between pa and myoepithelioma i.
Myoepitheliomas of minor salivary glands accounts to only 1. Myoepithelioma of minor salivary glands a diagnostic challenge. The topic malignant myoepithelioma of salivary gland you are seeking is a synonym, or alternative name, or is closely related to the medical condition myoepithelial carcinoma of salivary gland. This tumor is usually located in the parotid gland and the minor salivary glands of the soft palate and represents less than 1% of all salivary gland tumors. Myoepitheliomas are exceedingly rare cutaneous tumors that present as domeshaped, exophytic nodules on the face, neck, extremities, or trunk.